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Attribute | Details |
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Brand Name | Tibsovo |
Generic Name | Ivosidenib |
Drug Class | IDH1 inhibitor |
Uses | Treatment of acute myeloid leukemia (AML) with IDH1 mutation, cholangiocarcinoma with IDH1 mutation, and other IDH1-mutant cancers. |
Manufacturer | Agios Pharmaceuticals (now part of Servier) |
Approval | FDA-approved for AML and cholangiocarcinoma |
Dosage Form | Oral tablets (250 mg) |
Administration | Taken orally, typically once daily |
Side Effects | Common side effects include nausea, diarrhea, fatigue, and differentiation syndrome. |
Special Instructions | Can be taken with or without food; avoid high-fat meals. |
Tibsovo (ivosidenib) 250mg is a targeted cancer therapy used to treat certain cancers with IDH1 mutations, including acute myeloid leukemia (AML) and cholangiocarcinoma (bile duct cancer). Ivosidenib inhibits the mutated IDH1 enzyme, slowing cancer cell growth. Tibsovo is taken orally, typically 500 mg once daily. Assistance programs are available to help with cost, and it’s FDA-approved for its specific indications.
Tibsovo, the brand name for ivosidenib 250mg, inhibits mutant isocitrate dehydrogenase-1 (IDH1), an enzyme often mutated in cancers. By targeting this enzyme, Tibsovo slows cancer growth in cells relying on the mutated enzyme for survival.
FDA Approval and Indications
FDA Approval: Tibsovo (Ivosidenib) was approved by the FDA in July 2018 for treating acute myeloid leukemia (AML) with an IDH1 mutation.
Indications:
Cholangiocarcinoma: Tibsovo treats cholangiocarcinoma (bile duct cancer) with IDH1 mutations.
Acute Myeloid Leukemia (AML): Used in AML patients with the IDH1 mutation.
Astrocytoma: Currently under study for treating brain tumors like astrocytoma.
Cholangiocarcinoma: Provides a targeted therapy for patients with IDH1 mutations.
AML: Effectively addresses AML by targeting its underlying genetic mutation.
Astrocytoma & Brain Cancer: Research is ongoing to evaluate its effectiveness in treating brain tumors.
Dosage and Administration Tibsovo (Ivosidenib):
Tibsovo (Ivosidenib) is typically administered as an oral tablet, with a recommended dose of 500 mg daily.
Dosage may vary, so always follow your specialist advice.
Common Side Effects:
Nausea
Diarrhea
Decreased appetite
Vomiting
Serious Side Effects:
Differentiation syndrome (rapid cancer cell differentiation)
Liver issues (elevated liver enzymes).
Copay Card and Assistance Programs: Tibsovo offers copay assistance and patient support to ease financial burdens for eligible patients.
Availability in Different Countries:
Australia: Approved for specific uses.
Canada: Available through healthcare channels.
Manufacturer and Distribution
Agios Pharmaceuticals produce Tibsovo (Ivosidenib), in partnership with Servier for distribution. It’s available via specialized pharmacies and healthcare providers.
Research and Clinical Trials
Ongoing trials are investigating Tibsovo’s potential in other cancers and its use in combination with other therapies.
Regulatory and Safety Information
FDA and EMA Approvals: Tibsovo (Ivosidenib) 250mg is FDA- and EMA-approved for its specific uses, based on rigorous trials.
Safety and Monitoring: Regular health assessments, including liver function tests, are recommended.
Patient Assistance and Support
Copay Assistance Programs: Financial aid for eligible patients.
Patient Assistance Program: Offers medication access and financial help.
Comparison with Other Medications
Tibsovo (Ivosidenib) 250mg is compared with other IDH inhibitors for efficacy, side effects, and patient outcomes. Always consult with your doctor for the best treatment choice.
Conclusion
Tibsovo (Ivosidenib) is a cutting-edge cancer therapy that targets IDH1 mutations. By understanding its uses, side effects, and costs, patients can make informed treatment decisions.
FAQs
What is Tibsovo used for?
Tibsovo 250mg treats cancers with IDH1 mutations, such as AML, cholangiocarcinoma, and possibly brain tumors.
Does Tibsovo (Ivosidenib) have side effects?
Common side effects include nausea, fatigue, and diarrhea. Serious effects may involve liver issues and differentiation syndrome.
Is there a generic version of Tibsovo (Ivosenib) ?
Yes, Tibsovo (Ivosidenib) is available in a generic form at a lower cost.
How can I access Tibsovo (Ivosidenib) assistance programs?
Tibsovo offers copay and patient assistance programs.
Tibsovo price : Tibsovo price is depend much expensive. Generic Tibsovo is available at best price.
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