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Idhifa (Enasidenib) 100 mg is a medication primarily prescribed for the treatment of relapsed or refractory acute myeloid leukemia (AML) in adults with specific genetic mutations. It belongs to a class of drugs known as isocitrate dehydrogenase 2 (IDH2) inhibitors, which target mutated IDH2 enzymes found in certain leukemias. By inhibiting these mutated enzymes, Enacitib helps to restore normal cellular differentiation and reduce the proliferation of leukemia cells, thereby improving outcomes for patients with AML.
Here is a table summarizing the details of Enasidenib (Idhifa):
Attribute | Details |
---|---|
Dose | 100 mg orally once daily |
Brand Name | Idhifa |
Generic Name | Enasidenib |
Producer | Celgene Corporation |
Made In | Manufactured in the United States |
Indication | Relapsed or refractory AML with IDH2 mutation |
Administration | Oral |
Common Side Effects | Nausea, vomiting, diarrhea, jaundice, elevated bilirubin, decreased appetite, electrolyte imbalances |
Monitoring | CBCs, liver function tests, electrolytes, signs of differentiation syndrome |
Warnings | Differentiation syndrome, hepatotoxicity, tumor lysis syndrome |
Contraindications | None known, caution in severe hepatic impairment |
Pregnancy Category | May cause fetal harm, effective contraception required |
Breastfeeding | Not recommended |
Drug Interactions | Caution with UGT1A1 inducers/inhibitors |
Here are some key details about Enasidenib (Idhifa):
Enasidenib is an inhibitor of the IDH2 enzyme. Mutations in the IDH2 gene result in the production of an abnormal enzyme that produces 2-hydroxyglutarate (2-HG), which contributes to the development of cancer. By inhibiting this enzyme, enasidenib reduces the levels of 2-HG, helping to restore normal cellular differentiation.
Common side effects of enasidenib include:
Patients taking enasidenib should be monitored regularly for:
Enasidenib (Idhifa) is a targeted therapy for AML patients with an IDH2 mutation, offering a new avenue for treatment in a patient population with limited options. Proper monitoring and management of side effects are crucial for the safe use of this medication. Always consult with a healthcare provider for personalized medical advice.
Generic Name: | Enasidenib |
---|---|
Theraputic Category: | Anti-Cancer |
Pack Size: | 30’s |
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Online Medicine Pharmacy
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