Indication:
Ibutigen 140mg capsules, containing Ibrutinib as the active ingredient, are prescribed for treating specific cancers like chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and Waldenström’s macroglobulinemia.

Pharmacology:
Ibrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor, functions by binding irreversibly to and inhibiting the activity of BTK enzyme. BTK is pivotal in the B-cell receptor signaling pathway, crucial for the survival and proliferation of malignant B cells. Through BTK inhibition, Ibrutinib disrupts B-cell signaling, inducing apoptosis and halting cancer cell growth.

Dosage and Administration:
Typically, Ibutigen 140mg capsules are taken orally once daily, with or without food. Patients should swallow the capsules whole with water. Adjustments in dosage may be necessary based on individual patient response and tolerance to treatment.

Interaction:
Ibrutinib can interact with various medications, including strong CYP3A inhibitors and inducers, potentially impacting its metabolism and effectiveness. Patients should disclose all medications, supplements, and herbal products to their healthcare provider to avoid potential interactions.

Side Effects:
Common side effects of Ibutigen 140mg capsules may include diarrhea, nausea, fatigue, muscle pain, and bruising. More severe side effects such as bleeding, infections, cardiac arrhythmias, and hypertension may occur. Patients should promptly seek medical attention for severe or persistent side effects.

Precautions and Warnings:
Patients undergoing treatment with Ibutigen 140mg capsules should be closely monitored for potential adverse reactions, including bleeding, infections, and cardiac events. Use of Ibrutinib during pregnancy may pose fetal harm, necessitating contraception for both genders during treatment and a period thereafter. Breastfeeding is not advised while taking Ibutigen.

Overdose Effects:
In instances of Ibutigen 140mg capsule overdose, patients may experience exacerbated adverse effects such as bleeding, infections, and gastrointestinal symptoms. Overdose management typically involves supportive care and complication monitoring. Immediate medical attention is crucial if overdose is suspected.