Doptelet (Avatrombopag Maleate INN) 20 mg

1. Indications:

Avatropag 20 is indicated for the treatment of various conditions, including:

• Overactive bladder (OAB): It helps control symptoms such as urinary urgency, frequency, and incontinence by relaxing the bladder muscles.
• Neurogenic detrusor overactivity (NDO): It can be used to manage bladder dysfunction caused by neurological conditions such as multiple sclerosis or spinal cord injury.
• Urinary incontinence: Avatropag 20 may be prescribed to reduce involuntary loss of urine.

2. Pharmacology:

Avatropag 20 exerts its pharmacological effects by selectively blocking the action of acetylcholine at muscarinic receptors in the bladder, thereby reducing involuntary contractions of the bladder muscle and increasing bladder capacity. This action helps alleviate symptoms associated with overactive bladder and related conditions.

3. Dosage and Administration:

The dosage of Avatropag 20 may vary depending on the patient’s medical condition and response to treatment. Typically, the recommended starting dose is 20 mg once daily, administered orally with or without food. Dosage adjustments may be made by a healthcare professional based on individual patient needs and tolerability.

4. Interaction:

Avatropag 20 may interact with other medications, including:

• Anticholinergic drugs: Concurrent use of multiple anticholinergic medications may increase the risk of side effects such as dry mouth, constipation, and urinary retention.
• Drugs with anticholinergic properties: Certain medications, such as antihistamines, tricyclic antidepressants, and antipsychotics, may potentiate the anticholinergic effects of Avatropag 20.

Patients should inform their healthcare provider about all prescription, over-the-counter, and herbal medications they are taking before starting Avatropag 20 to avoid potential interactions.

5. Side Effects:

Common side effects associated with Avatropag 20 may include:

• Dry mouth
• Constipation
• Urinary retention
• Blurred vision
• Dry eyes
• Dyspepsia

Patients should report any persistent or bothersome side effects to their healthcare provider.

6. Precautions and Warnings:

Before using Avatropag 20, patients should be aware of the following precautions:

• Caution is advised in patients with narrow-angle glaucoma, as anticholinergic medications can increase intraocular pressure.
• Avatropag 20 should be used with caution in patients with urinary retention or severe constipation.
• Elderly patients may be more susceptible to the anticholinergic effects of Avatropag 20, increasing the risk of adverse reactions.

7. Overdose Effects:

In case of overdose with Avatropag 20, symptoms may include:

• Severe dry mouth
• Urinary retention
• Confusion
• Hallucinations
• Flushing
• Tachycardia

Patients experiencing symptoms of overdose should seek immediate medical attention or contact a poison control center for assistance.