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Idhifa (Enasidenib) 50 mg is a medication used in the treatment of relapsed or refractory acute myeloid leukemia (AML) with a specific genetic mutation. It belongs to a class of drugs known as isocitrate dehydrogenase 2 (IDH2) inhibitors, which work by blocking the activity of mutated IDH2 enzymes. Enacitib 50 mg offers a targeted therapy option for patients with AML harboring IDH2 mutations, helping to induce differentiation of leukemia cells and inhibit their proliferation.
1. Indications:
Enacitib (Enasidenib) 50 mg is indicated for the treatment of relapsed or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase 2 (IDH2) mutation.
2. Pharmacology:
Enacitib (Enasidenib) 50 mg exerts its pharmacological effects by selectively inhibiting mutated IDH2 enzymes, particularly those with the R140 and R172 substitutions. By blocking these mutated enzymes, Enacitib disrupts abnormal cellular metabolism, promotes differentiation of leukemia cells, and inhibits their proliferation, ultimately leading to suppression of leukemic growth.
3. Dosage and Administration:
The recommended dosage of Enacitib (Enasidenib) 50 mg is one tablet taken orally once daily, with or without food. Treatment should continue until disease progression, unacceptable toxicity, or other treatment discontinuation criteria are met. Dose adjustments or discontinuation may be necessary based on individual patient response and tolerability.
4. Interaction:
Enacitib (Enasidenib) 50 mg may interact with other medications, including:
Patients should inform their healthcare provider about all medications they are taking, including prescription, over-the-counter, and herbal products, to avoid potential interactions.
5. Side Effects:
Common side effects associated with Enacitib (Enasidenib) 50 mg may include:
Patients should report any persistent or severe side effects to their healthcare provider for further evaluation and management.
6. Precautions and Warnings:
Before using Enacitib (Enasidenib) 50 mg, patients should be aware of the following precautions:
7. Overdose Effects:
In case of overdose with Enacitib (Enasidenib) 50 mg, supportive care should be initiated, and symptomatic treatment may be administered as necessary. There is no specific antidote for Enacitib overdose, and patients should seek immediate medical attention if overdose is suspected.
Generic Name: | Enasidenib |
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Theraputic Category: | Anti-Cancer |
Pack Size: | 30’s |
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Online Medicine Pharmacy
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