Briganix (brigatinib) 90 mg

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BRIGANIX is approved for use in treating individuals with ALK-positive metastatic non-small cell lung cancer (NSCLC) who have either not responded to or cannot tolerate crizotinib. This approval, granted on an accelerated basis, is contingent upon the observed tumor response rate and the length of that response. The ongoing authorization for this specific use hinges on the outcomes and detailed findings from a confirmatory clinical trial that verifies and elaborates on the drug’s clinical benefits.

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    Overview of Briganix 90mg Tablets

    Composition: Contains Brigatinib 90mg.
    – Substitutes: Trepmac, Alunbrig.
    – Shipping Class: Room Temperature.

    Uses

    Primary Use: Treats a specific type of lung cancer known as non-small cell lung cancer (NSCLC) by inhibiting the growth of cancer cells.

    Side Effects

    Common Side Effects: May include nausea, vomiting, diarrhea, loss of appetite, abdominal pain, constipation, fatigue, dizziness, fever, headaches, insomnia, or joint pain. If these persist or worsen, contact a healthcare professional.

    How to Use

    -Administration Instructions: Take orally with or without food as prescribed by a healthcare provider. Swallow tablets whole without crushing or chewing.

    Mechanism of Action

    Function: Acts as an anaplastic lymphoma kinase (ALK) inhibitor, demonstrating significant effectiveness in treating ALK-positive NSCLC.

    Important Information

    – Monitoring for Pulmonary Reactions: Watch for symptoms of interstitial lung disease/pneumonitis, especially within the first week of treatment.
    – Blood Pressure Management: Manage blood pressure before starting treatment; monitor after two weeks and monthly thereafter.
    – Heart Rate Monitoring: Be aware of potential bradycardia; monitor heart rate and blood pressure regularly.
    – Visual Disturbances: Report any changes in vision.
    – Muscle Health: Increased creatine phosphokinase (CPK) levels can occur; report unexplained muscle symptoms and monitor CPK levels.
    – Pancreatic Enzymes: Monitor lipase and amylase levels due to potential increases.
    – Blood Sugar Levels: Assess and monitor fasting serum glucose; adjust antihyperglycemic medications as needed.

    Warnings and Precautions

    – Alcohol: May exacerbate dizziness or vision issues; limit alcohol consumption.
    – Pregnancy: Potential to harm the fetus; evaluate risks and benefits.
    – Lactation: Not recommended due to potential risk to the infant; consult a doctor before breastfeeding.
    – Driving: Exercise caution due to possible dizziness or vision blur.
    – Kidney Function: Use cautiously in patients with kidney disease; monitor kidney function closely.
    – Liver Function: Use cautiously in patients with liver disease; monitor liver function closely.

    Missed Dose Guidance

    – If a dose is missed, skip it and continue with the next dose at the regular schedule. Do not double the dose.

    Product Name

    Briganix

    Generic Name

    Brigatinib

    Formulation

    Tablet

    Available Pack Size

    30’s Pot

    Available Strength

    90 mg, 180 mg