Indication:
ABIRET (Abiraterone) 250mg is prescribed for the treatment of prostate cancer, particularly in cases where the cancer has progressed or spread. It is commonly used alongside other medications as part of a comprehensive cancer treatment plan.

Pharmacology:
Abiraterone operates by blocking the activity of an enzyme known as cytochrome P450 17α-hydroxylase/C17,20-lyase (CYP17), which is crucial for the production of androgens (male hormones) in the body. By inhibiting this enzyme, Abiraterone effectively reduces the production of androgens like testosterone, which fuel the growth of prostate cancer cells.

Dosage and Administration:
The recommended dose of ABIRET (Abiraterone) 250mg typically involves taking one tablet orally once a day. It is often combined with other medications such as prednisone or prednisolone. Dosage adjustments may be necessary based on individual patient factors and as directed by a healthcare provider.

Interaction:
Abiraterone has the potential to interact with various medications, particularly those metabolized by CYP3A4 enzymes, such as certain anticoagulants, anticonvulsants, and immunosuppressants. It’s important to inform healthcare providers about all medications, supplements, and herbal products being taken to prevent potential interactions.

Side Effects:
Common side effects linked with ABIRET (Abiraterone) 250mg may include fatigue, nausea, high blood pressure, fluid retention, hot flashes, joint pain or swelling, and gastrointestinal disturbances. Serious adverse reactions like liver toxicity, cardiovascular issues, and adrenal insufficiency may occur less frequently but necessitate immediate medical attention.

Precautions and Warnings:
Patients undergoing treatment with Abiraterone should be closely monitored for signs of liver toxicity, cardiovascular complications, and adrenal insufficiency. Regular assessments of liver function tests and blood pressure levels are essential. Caution is advised for patients with a history of cardiovascular disease or liver problems.

Overdose Effects:
In case of an overdose of ABIRET (Abiraterone) 250mg, supportive measures should be initiated, and the patient closely monitored for signs of adverse effects. There is no specific antidote for Abiraterone overdose, and management typically involves providing symptomatic and supportive care. Timely medical attention is crucial if an overdose is suspected.