Laronib (Larotrectinib INN)100 mg

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Laronib (Larotrectinib INN) is a medication indicated for the treatment of solid tumors displaying neurotrophic tyrosine receptor kinase (NTRK) gene fusion, without known acquired resistance mutations. It is suitable for various cancer types, including pediatric patients aged one year and older, adults with NTRK gene fusion solid tumors, and those with metastatic solid tumors who have exhausted other treatment options. Operating as a tyrosine kinase inhibitor, Laronib selectively targets tropomyosin receptor kinases (TRK) A, B, and C, hindering the growth and spread of cancer cells harboring NTRK gene fusions. The typical dosage is 100 mg taken orally twice daily, with or without food, with potential dosage adjustments based on individual response and tolerance. Patients should inform healthcare providers about all medications to avoid potential interactions, and regular monitoring for signs of adverse effects such as hepatotoxicity, neurotoxicity, and embryo-fetal toxicity is recommended. In case of overdose, supportive measures are advised, focusing on symptomatic and supportive care.

 

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    Indications: Laronib (Larotrectinib INN) is prescribed for treating solid tumors that exhibit neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation. It’s applicable to various cancer types, including pediatric patients aged one year and older, adults with NTRK gene fusion solid tumors, and those with metastatic solid tumors who have exhausted other treatment options.

    Pharmacology: Laronib (Larotrectinib INN) operates as a tyrosine kinase inhibitor, selectively targeting tropomyosin receptor kinases (TRK) A, B, and C. By inhibiting these receptors, it hampers the growth and spread of cancer cells carrying NTRK gene fusions.

    Dosage and Administration: Typically, Laronib (Larotrectinib INN) is prescribed at a dosage of 100 mg taken orally twice daily, with or without food. Adjustments to the dosage might be necessary based on individual patient response and tolerance.

    Interactions: Laronib (Larotrectinib INN) may interact with specific medications, particularly strong CYP3A inhibitors and inducers. Patients should inform healthcare providers about all medications to avoid potential interactions.

    Side Effects: Common side effects of Laronib (Larotrectinib INN) include fatigue, nausea, dizziness, vomiting, anemia, elevated liver enzyme levels, constipation, diarrhea, and cough. Serious adverse effects may comprise hepatotoxicity, neurotoxicity, and embryo-fetal toxicity.

    Precautions and Warnings: Patients undergoing treatment with Laronib (Larotrectinib INN) should be monitored for signs of hepatotoxicity, neurotoxicity, and embryo-fetal toxicity. Adjustments or discontinuation of the medication might be required based on the severity of adverse reactions.

    Overdose Effects: In case of overdose, supportive measures are warranted. Although specific effects of Laronib (Larotrectinib INN) overdose are limited in information, management should focus on symptomatic and supportive care

    Product Name

    Laronib

    Generic Name

    Larotrectinib INN

    Formulation

    Capsule

    Available Pack size

    30 Capsules

    Strengths

    100 mg